Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 8/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 7/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8023750 | 0.92 | MAPT (0.48) | SMARCA2SMARCA4ARRAB9AHTT | |
| SCHEMBL23831709 | 0.76 | SMARCA2 (0.56) | SMARCA2SMARCA4ARRAB9AHTT | |
| SCHEMBL30105045 | 0.76 | SMARCA2 (0.56) | SMARCA2SMARCA4ARRAB9AHTT | |
| SCHEMBL27968802 | 0.75 | SMARCA2 (0.72) | SMARCA2SMARCA4EPHX2NR1H4LMNA | |
| SCHEMBL23831856 | 0.74 | SMARCA2 (0.53) | SMARCA2SMARCA4ARRAB9AHTT | |
| SCHEMBL1973106 | 0.74 | IGF1R (0.41) | AURKARAB9AGRIK1 | |
| SCHEMBL22125204 | 0.72 | SMARCA2 (0.74) | SMARCA2SMARCA4RAB9ANPC1LMNA | |
| SCHEMBL8015251 | 0.72 | AR (0.46) | ARHTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL8005353 | 0.70 | CNR1 (0.46) | ARHTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL8017617 | 0.70 | AR (0.51) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252591-B1 | ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI AVENTIS (FR) | 2011-06-22 | — | — | EP | disclosed |
| WO-2009097999-A1 | ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |