Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011189 | 0.90 | MAPT (0.66) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL8024108 | 0.90 | MAPT (0.66) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL787640 | 0.83 | KDR (0.64) | MAPTABCG2KDRNPSR1MEN1 | |
| SCHEMBL8010530 | 0.76 | SMO (0.48) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL8011266 | 0.75 | MAPT (0.68) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL7918654 | 0.74 | MAPT (0.87) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL8021598 | 0.73 | NPSR1 (0.79) | MAPTKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL806038 | 0.73 | KDR (0.64) | MAPTKDRNPSR1MEN1TP53 | |
| SCHEMBL4201889 | 0.71 | ATM (0.63) | ALDH1A1 | |
| SCHEMBL7912029 | 0.71 | NPSR1 (0.72) | KDM4EALDH1A1KDRNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975605-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046574-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-22 | — | — | WO | disclosed |