Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024334 | 1.00 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL14587140 | 1.00 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL12230330 | 1.00 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL8281749 | 0.88 | — | — | |
| SCHEMBL8281845 | 0.88 | — | — | |
| SCHEMBL14226409 | 0.86 | — | — | |
| SCHEMBL12996332 | 0.85 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL14587141 | 0.85 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL13039016 | 0.85 | GRM5 (0.32) | GRM5KDM4EMAPTHSD17B10 | |
| SCHEMBL3447888 | 0.84 | HDAC1 (0.32) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156905-A | Deoxy epothilones and intermediates utilized in the process for preparing epothilones | NOVARTIS AG (CH) | 2000-12-05 | — | — | US | disclosed |
| US-6043372-A | USEFUL CHEMICAL INTERMEDIATES FOR ANTICARCINOGENIC EPITHILONES | NOVARTIS AG (CH) | 2000-03-28 | — | — | US | disclosed |
| US-5969145-A | Process for the production of epothilones and intermediate products within the process | NOVARTIS AG (CH) | 1999-10-19 | — | — | US | disclosed |
| EP-0923583-A1 | METHOD FOR PRODUCING EPOTHILONES, AND INTERMEDIATE PRODUCTS OBTAINED DURING THE PRODUCTION PROCESS | Novartis AG (CH) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008849-A1 | METHOD FOR PRODUCING EPOTHILONES, AND INTERMEDIATE PRODUCTS OBTAINED DURING THE PRODUCTION PROCESS | NOVARTIS AKTIENGESELLSCHAFT (CH) | 1998-03-05 | — | — | WO | disclosed |