SCHEMBL8026993

SCHEMBL8026993

c1onnc1N1CCCC1.c1onnc1N1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.42
HPGD P15428 3/20 0.38
CHRM3 P20309 1/20 0.36
PDE4A P27815 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE4C Q08493 1/20 0.36
PDE4D Q08499 1/20 0.36
SMN1; SMN2 Q16637 5/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
ALDH1A1 P00352 4/20 0.34
MAPK1 P28482 2/20 0.34
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
HTT P42858 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
CASP1 P29466 1/20 0.33
CASP4 P49662 1/20 0.33
CASP5 P51878 1/20 0.33
CNR2 P34972 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL478677 1.00 CYP1A2 (0.42) CYP1A2HPGDCHRM3PDE4APDE4B
SCHEMBL4552615 0.98 CYP1A2 (0.39) CYP1A2HPGDCHRM3PDE4APDE4B
SCHEMBL31097966 0.93
SCHEMBL23152060 0.83 KMT2A (0.42) CYP1A2SMN1; SMN2CRHBPCRHR2ALDH1A1
Hydrochloric Acid SCHEMBL27818600 0.81 KMT2A (0.41) CYP1A2SMN1; SMN2CRHBPCRHR2ALDH1A1
SCHEMBL20395811 0.79 BPTF (0.46) CYP1A2HPGDALDH1A1MAPK1HTT
SCHEMBL232813 0.70
SCHEMBL14503215 0.69 CYP1A2 (0.75) CYP1A2HPGDSMN1; SMN2ALDH1A1MAPK1
SCHEMBL15551479 0.67 KMT2A (0.38) CYP1A2HPGDALDH1A1NPC1RAB9A
SCHEMBL28246071 0.66 MAPT (0.41) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0981539-A1 DOLASTATIN 15 DERIVATIVES WITH CARBONYL AND HETEROCYCLIC FUNCTIONALITIES AT THE C-TERMINUS BASF AKTIENGESELLSCHAFT (DE) 2000-03-01 EP disclosed
WO-1998040400-A1 DOLASTATIN 15 DERIVATIVES WITH CARBONYL AND HETEROCYCLIC FUNCTIONALITIES AT THE C-TERMINUS BASF AKTIENGESELLSCHAFT (DE) 1998-09-17 WO disclosed