SCHEMBL8028916

SCHEMBL8028916

O=C(O)c1[nH]c2cccc(Br)c2c1Cl

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 3/20 0.58
FEN1 P39748 1/20 0.44
MCL1 Q07820 1/20 0.41
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
PBRM1 Q86U86 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9038402 0.83 GPR17 (0.61) GPR17FEN1MCL1KDM4EALDH1A1
SCHEMBL31332450 0.83 GPR17 (0.61) GPR17FEN1MCL1KDM4EALDH1A1
SCHEMBL27396667 0.81 GPR17 (0.60) GPR17FEN1KDM4EALDH1A1HPGD
SCHEMBL9272732 0.81 GPR17 (0.60) GPR17FEN1MCL1KDM4EALDH1A1
SCHEMBL28784146 0.80 GPR17 (0.48) GPR17FEN1MCL1KDM4EALDH1A1
SCHEMBL3255506 0.76 GPR17 (0.55) GPR17FEN1MCL1KDM4EALDH1A1
SCHEMBL29715192 0.76 GPR17 (0.55) GPR17FEN1KDM4EALDH1A1HPGD
SCHEMBL9186177 0.74 GPR17 (1.00) GPR17KDM4EALDH1A1
SCHEMBL31416400 0.74 GPR17 (0.48) GPR17MCL1
SCHEMBL29777587 0.74 FEN1 (0.47) GPR17FEN1KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0776907-B1 Process for producing platelet factor-4 JAPAN CHEM RES (JP) 2000-03-08 EP disclosed
US-5847084-A Process for obtaining platelet factor-4 JCR PHARMACEUTICALS CO., LTD. (JP) 1998-12-08 US disclosed
EP-0776907-A2 Process for producing platelet factor-4 JCR PHARMACEUTICALS Co., LTD. (JP) 1997-06-04 EP disclosed