SCHEMBL8029188

SCHEMBL8029188

CCC#CCc1ccc(C#Cc2ccc(-c3ccc(CCC)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACACB O00763 5/20 0.46
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
FFAR1 O14842 4/20 0.37
FFAR4 Q5NUL3 3/20 0.37
MCL1 Q07820 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP1B1 Q16678 1/20 0.36
HRH3 Q9Y5N1 1/20 0.35
LPL P06858 1/20 0.35
LIPG Q9Y5X9 1/20 0.35
NISCH Q9Y2I1 1/20 0.35
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
RAB9A P51151 1/20 0.34
GFER P55789 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8046404 0.95 ACACB (0.49) ACACBFFAR1FFAR4LPLLIPG
SCHEMBL9333056 0.89 TSHR (0.45) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL8729713 0.89 HSD17B10 (0.58) TSHRHSD17B10FFAR1FFAR4HRH3
SCHEMBL8029369 0.88 TSHR (0.41) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL8042641 0.86 TSHR (0.42) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL8040947 0.85 TSHR (0.46) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL8039120 0.84 ACACB (0.38) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL9333020 0.84 CYP1A1 (0.53) ACACBTSHRHSD17B10FFAR1FFAR4
SCHEMBL9335901 0.83 ACACB (0.47) ACACBFFAR1FFAR4LPLLIPG
SCHEMBL8042911 0.83 RARB (0.40) ACACBTSHRHSD17B10FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727473-B1 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-01-12 EP disclosed
US-5833879-A LOW TEMPERATURE MISCIBILITY AND COMPATIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS; DISPLAYS CONTAINING MIXTURES OF AT LEAST TWO COMPOUNDS, PHYSICAL PROPERTIES CHISSO CORPORATION (JP) 1998-11-10 US disclosed
EP-0727473-A2 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1996-08-21 EP disclosed