Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029266 | 1.00 | ACE (0.42) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL8029268 | 1.00 | ACE (0.42) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL8046311 | 0.96 | ACE (0.38) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL8046308 | 0.96 | ACE (0.38) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL7350501 | 0.77 | ACE (0.46) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL8863112 | 0.77 | ACE (0.46) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL386126 | 0.71 | ACE (0.61) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL385803 | 0.71 | ACE (0.61) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL386486 | 0.71 | ACE (0.61) | ACECYP3A4TSHRTDP1MAPT | |
| Hydrochloric Acid SCHEMBL11148459 | 0.70 | ACE (0.59) | ACECYP3A4TSHRTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747392-B1 | 1,2-Diazepine containing dual action inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2000-11-02 | — | — | EP | disclosed |
| US-5635504-A | Diazepine containing dual action inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0747392-A1 | 1,2-Diazepine containing dual action inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |