Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | CASP3 | P42574 | 2/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13561098 | 0.90 | MAOB (0.70) | MAOBRAB9ANPC1CASP3SENP8 | |
| SCHEMBL7299491 | 0.81 | KDM4E (0.62) | NPC1KDM4EALDH1A1MCL1CYP3A4 | |
| SCHEMBL6702416 | 0.79 | CA9 (0.64) | MAOBNPC1MAOAKDM4EALDH1A1 | |
| SCHEMBL31293440 | 0.79 | KDM4E (0.56) | MAOBNPC1KDM4EALDH1A1MCL1 | |
| SCHEMBL107774 | 0.78 | MAOB (1.00) | MAOBRAB9ANPC1CASP3SENP8 | |
| SCHEMBL29382160 | 0.78 | MAOB (1.00) | MAOBRAB9ANPC1CASP3SENP8 | |
| SCHEMBL8807762 | 0.77 | KDM4E (0.70) | MAOBMAOAKDM4EALDH1A1MCL1 | |
| SCHEMBL11095625 | 0.76 | HSD17B3 (0.63) | MAOBRAB9ANPC1CASP3SENP8 | |
| Metesculetol SCHEMBL29649664 | 0.75 | KDM4E (0.62) | MAOBKDM4EALDH1A1MCL1CYP3A4 | |
| Metesculetol SCHEMBL1053452 | 0.75 | KDM4E (0.62) | MAOBKDM4EALDH1A1MCL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053193-C | Esculetin derivatives, process for manufacture and use thereof, and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2000-06-07 | — | — | CN | disclosed |
| EP-0654479-B1 | Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2000-03-15 | — | — | EP | disclosed |
| CN-1106398-A | Esculetin derivatives, process for manufacture and use thereof, and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 1995-08-09 | — | — | CN | disclosed |
| EP-0654479-A2 | Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-05-24 | — | — | EP | disclosed |