Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029125 | 0.80 | GRM5 (0.56) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9763278 | 0.80 | GRM5 (0.56) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8019557 | 0.75 | GRM5 (0.51) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10536487 | 0.74 | GRM5 (0.50) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10536476 | 0.74 | GRM5 (0.50) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2713936 | 0.72 | GRM5 (1.00) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2717540 | 0.72 | GRM5 (0.69) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2716206 | 0.71 | GRM5 (0.67) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8019571 | 0.70 | GRM5 (0.58) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9835747 | 0.69 | GRM5 (0.51) | GRM5ALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| CN-1024663-C | Substituted tetralins for treating asthma | PFIZER (US) | 1994-05-25 | — | — | CN | disclosed |
| CN-1021823-C | Substituted chroman compounds for treatment of asthma, arthritis and the like | PFIZER (US) | 1993-08-18 | — | — | CN | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| CN-1064864-A | The tetraline that replaces and the preparation method of allied compound | PFIZER (US) | 1992-09-30 | — | — | CN | disclosed |
| CN-1063489-A | Substituted benzotetrahydropyridines and related compounds | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| CN-1033277-A | Substituted tetralinchromans and related compounds for the treatment of asthma | PFIZER (US) | 1989-06-07 | — | — | CN | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| CN-1032659-A | Substituted tetralins, chromans and like compounds for the treatment of asthma, arthritis and like diseases | PFIZER (US) | 1989-05-03 | — | — | CN | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0313296-A2 | Substituted chromans and related compounds in the treatment of asthma | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |