Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021604 | 0.88 | PLK1 (0.48) | MAPTALDH1A1CYP19A1MEN1KMT2A | |
| SCHEMBL3255840 | 0.81 | MAPT (0.56) | MAPTHPGDLMNAALDH1A1SMPD1 | |
| SCHEMBL3691078 | 0.80 | MAPT (0.55) | MAPTHPGDLMNAALDH1A1SMPD1 | |
| SCHEMBL13592956 | 0.79 | MAPT (0.54) | MAPTHPGDLMNAALDH1A1SMPD1 | |
| SCHEMBL3249294 | 0.77 | MAPT (0.52) | MAPTHPGDLMNAALDH1A1CYP19A1 | |
| SCHEMBL3256911 | 0.74 | PLK1 (0.62) | PLK1 | |
| SCHEMBL3255455 | 0.74 | PLK1 (0.62) | PLK1 | |
| SCHEMBL29179284 | 0.73 | HPGD (0.54) | MAPTHPGDLMNAALDH1A1SMPD1 | |
| SCHEMBL2498156 | 0.73 | KMT2A (0.66) | MAPTHPGDLMNAALDH1A1MEN1 | |
| SCHEMBL21957654 | 0.70 | HPGD (0.54) | MAPTHPGDLMNAALDH1A1SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121202-A | 2-((THIENYL OR FURYL) (OXY OR THIO))-PYRIDINE AND 6-((THIENYL OR FURYL) (OXY OR THIO))-PYRIMIDINE COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2000-09-19 | — | — | US | disclosed |