Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14236276 | 0.94 | BRAF (0.48) | BRAF | |
| SCHEMBL14236414 | 0.93 | BRAF (0.49) | BRAF | |
| SCHEMBL14235964 | 0.93 | BRAF (0.50) | BRAF | |
| SCHEMBL8034672 | 0.92 | BRAF (0.48) | BRAF | |
| SCHEMBL14236134 | 0.91 | BRAF (0.48) | BRAF | |
| SCHEMBL14236068 | 0.87 | BRAF (0.53) | BRAF | |
| SCHEMBL14236417 | 0.87 | BRAF (0.48) | BRAF | |
| SCHEMBL14236284 | 0.86 | BRAF (0.50) | BRAF | |
| SCHEMBL14236470 | 0.86 | BRAF (0.53) | BRAF | |
| SCHEMBL14236422 | 0.86 | BRAF (0.47) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265610-B1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |