Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | CLK1 | P49759 | 4/20 | 0.54 |
| ▸ | BLM | P54132 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.54 |
| ▸ | CLK3 | P49761 | 2/20 | 0.54 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.54 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035944 | 0.88 | DYRK1A (0.60) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL8030001 | 0.80 | MEN1 (0.66) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL8020265 | 0.77 | MEN1 (0.62) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL8030185 | 0.75 | HSD17B10 (0.64) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL8033454 | 0.75 | MEN1 (0.53) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL24534821 | 0.73 | DYRK1A (0.70) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL24718937 | 0.72 | MAPT (1.00) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL2977830 | 0.71 | DYRK1A (1.00) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL2977826 | 0.71 | DYRK1A (1.00) | MAPTHSD17B10ALDH1A1HTTNPSR1 | |
| SCHEMBL4157023 | 0.70 | DYRK1A (0.76) | MAPTHSD17B10ALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |