SCHEMBL8034811

SCHEMBL8034811

CC(Oc1c(Cl)cc(NC(=O)NC(=O)c2c(F)cccc2F)c(F)c1Cl)C(F)(F)C(F)(F)F

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.62
KMT2A Q03164 3/20 0.62
MAPT P10636 2/20 0.52
USP2 O75604 1/20 0.52
ALOX15 P16050 1/20 0.52
ATM Q13315 1/20 0.41
POLB P06746 1/20 0.39
DHODH Q02127 7/20 0.39
KDM4E B2RXH2 2/20 0.37
NPC1 O15118 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPK1 P28482 1/20 0.37
GAA P10253 2/20 0.36
TRPA1 O75762 1/20 0.36
THRB P10828 1/20 0.35
RECQL P46063 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
TLR7 Q9NYK1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8031280 0.86 MEN1 (0.48) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL10720041 0.82 KMT2A (0.74) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL10615840 0.82 MEN1 (0.67) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL29044367 0.82 MEN1 (0.63) MEN1KMT2AMAPTUSP2ALOX15
Noviflumuron SCHEMBL15124761 0.80 MEN1 (0.72) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8032960 0.80 MEN1 (0.46) MEN1KMT2AMAPTUSP2ALOX15
Noviflumuron SCHEMBL26022 0.80 MEN1 (0.72) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL9797130 0.80 MEN1 (0.64) MEN1KMT2AMAPTUSP2ALOX15
Teflubenzuron SCHEMBL4217571 0.78 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Teflubenzuron SCHEMBL29352804 0.78 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6040345-A Benzoylphenylurea insecticides and methods of using them to control cockroaches DOW AGROSCIENCES LLC (US) 2000-03-21 US claimed
US-6040345-A Benzoylphenylurea insecticides and methods of using them to control cockroaches DOW AGROSCIENCES LLC (US) 2000-03-21 US disclosed
WO-1998019995-A1 NEW BENZOYLPHENYLUREA INSECTICIDES ANS METHODS OF USING THEM TO CONTROL COCKROACHES DOW AGROSCIENCES LLC (US) 1998-05-14 WO disclosed