SCHEMBL8035007

SCHEMBL8035007

COc1cccc(-c2c(N)c(N)nn2Cc2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.58
NR1H3 Q13133 1/20 0.58
SLC16A3 O15427 1/20 0.52
SLC16A1 P53985 1/20 0.52
MCTS1 Q9ULC4 1/20 0.52
KMT2A Q03164 1/20 0.48
SIGMAR1 Q99720 3/20 0.47
HTR1A P08908 2/20 0.47
DRD4 P21917 2/20 0.47
HTR2C P28335 2/20 0.47
HTR2B P41595 2/20 0.47
SLC6A3 Q01959 2/20 0.47
TMEM97 Q5BJF2 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
ADRA2A P08913 1/20 0.47
ADRA2B P18089 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8034801 0.90 SMN1; SMN2 (0.49) NR1H2NR1H3SLC16A3SLC16A1MCTS1
SCHEMBL8035070 0.86 CYP1A2 (0.60) NR1H2NR1H3SIGMAR1CYP1A2CYP3A4
SCHEMBL8034876 0.84 BACE1 (0.43) NR1H2NR1H3KMT2ACYP3A4DPP4
SCHEMBL8038673 0.83 TP53 (0.50) NR1H2NR1H3KMT2ACYP1A2CYP3A4
SCHEMBL8035242 0.82 SMN1; SMN2 (0.53) NR1H2NR1H3KMT2AADORA2ASMN1; SMN2
SCHEMBL8036883 0.82 TLR8 (0.46) NR1H2NR1H3KMT2ADPP4ADORA2A
SCHEMBL8025282 0.78 GRIN1 (0.54) NR1H2NR1H3SLC16A3SLC16A1MCTS1
SCHEMBL8025270 0.77 ADORA2A (0.48) KMT2ACYP3A4DPP4ADORA2ABACE1
SCHEMBL8025183 0.76 KDM4E (0.51) NR1H2NR1H3KMT2ACYP1A2CYP3A4
SCHEMBL8025209 0.75 KDM4E (0.44) KMT2ACYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6090162-A THE META-AMINOPHENOL IS HALOGENATED AT THE ORTHO POSITION OF THE PHENOL AS A COUPLER; DYEING USING THIS COMPOSITION WITH AN OXIDIZING AGENT; MULTICOMPARTMENT DYE KIT; USE AS HAIR DYE RESISTANT TO LIGHT, SHAMPOO, PERM TREATMENTS L'OREAL S.A. (FR) 2000-07-18 US claimed
EP-0919221-A1 Oxidative dyeing composition for keratinic fibres containing a substituted 3,4 diaminopyrazole-5 and a halogenated meta-aminophenol and dyeing process L'OREAL (FR) 1999-06-02 EP claimed
EP-0900206-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1999-03-10 EP claimed
WO-1997042173-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1997-11-13 WO claimed
US-6118008-A FIBER-REACTIVE DYE; HAIR DYE L'OREAL (FR) 2000-09-12 US disclosed
US-6090162-A THE META-AMINOPHENOL IS HALOGENATED AT THE ORTHO POSITION OF THE PHENOL AS A COUPLER; DYEING USING THIS COMPOSITION WITH AN OXIDIZING AGENT; MULTICOMPARTMENT DYE KIT; USE AS HAIR DYE RESISTANT TO LIGHT, SHAMPOO, PERM TREATMENTS L'OREAL S.A. (FR) 2000-07-18 US disclosed
EP-0919221-A1 Oxidative dyeing composition for keratinic fibres containing a substituted 3,4 diaminopyrazole-5 and a halogenated meta-aminophenol and dyeing process L'OREAL (FR) 1999-06-02 EP disclosed
EP-0900206-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1999-03-10 EP disclosed
WO-1997042173-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1997-11-13 WO disclosed