SCHEMBL8035176

SCHEMBL8035176

Cc1c(N)c(N)nn1Cc1ccc(Cl)cc1

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.76
GFER P55789 1/20 0.76
POLB P06746 2/20 0.57
SLC2A1 P11166 1/20 0.55
KDM4E B2RXH2 2/20 0.54
KMT2A Q03164 6/20 0.49
MEN1 O00255 5/20 0.49
SMN1; SMN2 Q16637 5/20 0.49
MAPT P10636 3/20 0.49
LMNA P02545 5/20 0.44
STAT3 P40763 1/20 0.44
RECQL P46063 1/20 0.41
TSHR P16473 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.40
HTT P42858 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11655968 0.86 GAA (1.00) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL8034840 0.84 KDM4E (0.75) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL20281262 0.82 GAA (0.53) GAAGFERSLC2A1KDM4EKMT2A
SCHEMBL8034995 0.80 GAA (0.54) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL8038668 0.79 GAA (0.53) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL8038817 0.79 GAA (0.53) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL8041029 0.79 SMN1; SMN2 (0.59) GAAGFERPOLBSLC2A1KMT2A
SCHEMBL8038867 0.78 GAA (0.51) GAAGFERPOLBSLC2A1KDM4E
SCHEMBL8041057 0.78 GAA (0.51) GAAGFERPOLBKMT2AMEN1
SCHEMBL8038819 0.77 GAA (0.50) GAAGFERPOLBSLC2A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6090162-A THE META-AMINOPHENOL IS HALOGENATED AT THE ORTHO POSITION OF THE PHENOL AS A COUPLER; DYEING USING THIS COMPOSITION WITH AN OXIDIZING AGENT; MULTICOMPARTMENT DYE KIT; USE AS HAIR DYE RESISTANT TO LIGHT, SHAMPOO, PERM TREATMENTS L'OREAL S.A. (FR) 2000-07-18 US claimed
EP-0919221-A1 Oxidative dyeing composition for keratinic fibres containing a substituted 3,4 diaminopyrazole-5 and a halogenated meta-aminophenol and dyeing process L'OREAL (FR) 1999-06-02 EP claimed
EP-0900206-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1999-03-10 EP claimed
WO-1997042173-A1 NEW DIAMINO PYRAZOLS, THEIR SYNTHESIS, KERATIN FIBRE DYEING COMPOSITIONS CONTAINING THEM, KERATIN FIBRE DYEING METHODS L'OREAL (FR) 1997-11-13 WO claimed
US-6118008-A FIBER-REACTIVE DYE; HAIR DYE L'OREAL (FR) 2000-09-12 US disclosed
US-6090162-A THE META-AMINOPHENOL IS HALOGENATED AT THE ORTHO POSITION OF THE PHENOL AS A COUPLER; DYEING USING THIS COMPOSITION WITH AN OXIDIZING AGENT; MULTICOMPARTMENT DYE KIT; USE AS HAIR DYE RESISTANT TO LIGHT, SHAMPOO, PERM TREATMENTS L'OREAL S.A. (FR) 2000-07-18 US disclosed
EP-0919221-A1 Oxidative dyeing composition for keratinic fibres containing a substituted 3,4 diaminopyrazole-5 and a halogenated meta-aminophenol and dyeing process L'OREAL (FR) 1999-06-02 EP disclosed