Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035630 | 0.89 | LSS (0.60) | LSSPPARDRXRARXRBMAPT | |
| SCHEMBL8047705 | 0.84 | PPARD (0.38) | LSSPPARDMAPTNPC1RAB9A | |
| SCHEMBL8045112 | 0.80 | PPARD (0.55) | LSSPPARDRXRARXRBMAPT | |
| SCHEMBL8903933 | 0.80 | PPARD (0.55) | LSSPPARDRXRARXRBMAPT | |
| SCHEMBL7767865 | 0.80 | LSS (0.44) | LSSPPARDMAPTNPC1RAB9A | |
| SCHEMBL7771940 | 0.79 | LSS (0.52) | LSSMAOBMEN1KMT2A | |
| SCHEMBL7688154 | 0.79 | LSS (0.52) | LSSMAOBMEN1KMT2A | |
| SCHEMBL8035571 | 0.79 | LSS (0.52) | LSSSRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL9360246 | 0.78 | LSS (0.46) | LSSMAPTNPC1RAB9AHTT | |
| SCHEMBL3675142 | 0.78 | LSS (0.78) | LSSPPARDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | claimed |