Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 9/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.49 |
| ▸ | CLK3 | P49761 | 3/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.47 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035434 | 0.92 | DYRK1A (0.51) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8031846 | 0.91 | DYRK1A (0.50) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4019249 | 0.83 | DYRK1A (0.70) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8029736 | 0.83 | DYRK1A (0.70) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8029999 | 0.82 | DYRK1A (0.69) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012203 | 0.79 | DYRK1A (0.48) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8029989 | 0.77 | DYRK1A (0.47) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8032119 | 0.77 | CLK1 (0.74) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012705 | 0.77 | CLK1 (0.61) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8031540 | 0.77 | DYRK1A (0.65) | DYRK1AHTR2AHTR2CCLK1CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |