Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505955 | 1.00 | SPHK1 (0.52) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10903262 | 0.99 | SPHK1 (0.55) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10903254 | 0.99 | SPHK1 (0.55) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10788260 | 0.97 | SPHK1 (0.55) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10788269 | 0.97 | SPHK1 (0.55) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10903261 | 0.96 | SPHK1 (0.54) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10903264 | 0.96 | SPHK1 (0.54) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL8792205 | 0.96 | SPHK1 (0.54) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL8792195 | 0.96 | SPHK1 (0.54) | SPHK1CYP2C9SPHK2MAPTALDH1A1 | |
| SCHEMBL10901563 | 0.96 | SPHK1 (0.54) | SPHK1CYP2C9SPHK2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497176-B1 | Four rings compounds and liquid crystal mixtures containing them | MERCK PATENT GMBH (DE) | 2000-04-05 | — | — | EP | disclosed |
| US-4613208-A | ELECTROOPTICS; ULTRAVIOLET RADIATION STABILITY; QUICK RESPONSE | HOFFMANN-LA ROCHE INC. (US) | 1986-09-23 | — | — | US | disclosed |
| US-4583826-A | Phenylethanes | HOFFMANN-LA ROCHE INC. (US) | 1986-04-22 | — | — | US | disclosed |
| EP-0110205-A2 | Coloured liquid crystal mixtures containing phenyl ethanes | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-06-13 | — | — | EP | disclosed |