Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 10/20 | 0.71 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9148408 | 0.99 | LSS (0.72) | LSSNSD2PYCR1SIGMAR1TMEM97 | |
| Hydrochloric Acid SCHEMBL9152624 | 0.83 | LSS (0.79) | LSSPYCR1ACHEMEN1KMT2A | |
| SCHEMBL9150936 | 0.83 | LSS (0.76) | LSSPYCR1ACHE | |
| SCHEMBL4314508 | 0.83 | LSS (1.00) | LSSPYCR1ACHEMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9150554 | 0.82 | LSS (0.77) | LSSNSD2PYCR1ACHE | |
| SCHEMBL14142956 | 0.80 | LSS (0.71) | LSSPYCR1ACHENPC1 | |
| SCHEMBL9151950 | 0.80 | LSS (0.56) | LSSNSD2MEN1KMT2A | |
| SCHEMBL3675147 | 0.79 | LSS (0.70) | LSSPYCR1SIGMAR1TMEM97ACHE | |
| Hydrochloric Acid SCHEMBL8049750 | 0.78 | LSS (0.70) | LSSPYCR1SIGMAR1TMEM97ACHE | |
| Hydrochloric Acid SCHEMBL9147192 | 0.78 | LSS (0.70) | LSSPYCR1SIGMAR1TMEM97POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | claimed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | claimed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | claimed |
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |