Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 5/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8036023 | 1.00 | GSR (0.57) | GSRGRIK1GRIK2CYP2A6KIF11 | |
| Lysine SCHEMBL3181984 | 0.87 | GSR (0.59) | GSRKIF11THRBPOLBKMT2A | |
| Anisaldehyde SCHEMBL7617228 | 0.85 | GSR (0.53) | GSRGRIK1GRIK2CYP2A6KIF11 | |
| Anisaldehyde SCHEMBL7617225 | 0.85 | GSR (0.53) | GSRGRIK1GRIK2CYP2A6KIF11 | |
| Lysine SCHEMBL8039073 | 0.85 | GSR (0.53) | GSRKIF11THRBPOLBKMT2A | |
| Lysine SCHEMBL8039075 | 0.85 | GSR (0.53) | GSRKIF11THRBPOLBKMT2A | |
| Lysine SCHEMBL7792553 | 0.84 | GSR (0.56) | GSRGRIK1GRIK2KIF11POLB | |
| Lysine SCHEMBL7800937 | 0.84 | GSR (0.56) | GSRGRIK1GRIK2KIF11POLB | |
| Lysine SCHEMBL7800114 | 0.84 | GSR (0.51) | GSRGRIK1GRIK2KIF11THRB | |
| Lysine SCHEMBL7792302 | 0.83 | GSR (0.54) | GSRGRIK1GRIK2KIF11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |