Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Acetate SCHEMBL8033586 | 0.81 | MAPK8 (0.54) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| Hydroquinone SCHEMBL8042120 | 0.79 | MAPK8 (0.59) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL8037988 | 0.78 | MAPK8 (0.50) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| Ethyl Chloride SCHEMBL8050699 | 0.77 | MAPK8 (0.61) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| Acetic Acid Phenyl Ester SCHEMBL8045094 | 0.74 | ELANE (0.51) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL11430427 | 0.73 | MAPK8 (0.79) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL8042507 | 0.73 | MAPK9 (0.56) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL8043300 | 0.72 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL8042773 | 0.72 | MAPK8 (0.61) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL6746930 | 0.70 | MAPK8 (0.69) | MAPK8MAPK9MAPK10MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143765-A | ENZYME IHIBITORS OF PROTEIN | SUGEN, INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |