Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379763 | 0.98 | CHRM1 (0.49) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| SCHEMBL2901294 | 0.98 | CHRM1 (0.49) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| SCHEMBL2908533 | 0.98 | CHRM1 (0.49) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL28915471 | 0.96 | CHRM1 (0.48) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL28577066 | 0.96 | CHRM1 (0.48) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL28577068 | 0.96 | CHRM1 (0.48) | CHRM1CNR1CNR2GSK3BDYRK1A | |
| SCHEMBL20434091 | 0.81 | CYP1A2 (0.48) | CHRM1GSK3BDYRK1ACYP1A2TDP1 | |
| SCHEMBL15431899 | 0.81 | CYP1A2 (0.48) | CHRM1GSK3BDYRK1ACYP1A2TDP1 | |
| SCHEMBL17625631 | 0.81 | CYP1A2 (0.48) | CHRM1GSK3BDYRK1ACYP1A2TDP1 | |
| SCHEMBL7995036 | 0.79 | TSHR (0.41) | LMNAALOX15TSHRHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232751-B1 | 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECANE AND ANALOGS | E.R. Squibb & Sons, Inc. (US) | 1991-09-11 | — | — | EP | claimed |
| US-4885363-A | RADIOPHARMACEUTICAL IMAGING; MEDICAL DIAGNOSIS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | claimed |
| EP-0292689-A2 | Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs | BRACCO INTERNATIONAL B.V. (NL) | 1988-11-30 | — | — | EP | claimed |
| EP-0232751-A1 | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs | E.R. Squibb & Sons, Inc. (US) | 1987-08-19 | — | — | EP | claimed |
| US-6143274-A | IMAGING MAMMALIAN TISSUE UTILIZING A NON-IONIC COMPLEX OF A PARAMAGNETIC ION OF LANTHANIDE ELEMENT AND A MACROCYCLIC CHELATING AGENT | BRACCO DIAGNOSTICS, INC. | 2000-11-07 | — | — | US | disclosed |
| US-5846519-A | Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs | BRACCO DIAGNOSTICS INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5674470-A | Method for imaging mammalian tissue using 1-substituted- 4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs | BRACCO DIAGNOSTICS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0292689-B1 | Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs | BRACCO INT BV (NL) | 1996-07-31 | — | — | EP | disclosed |
| US-5474756-A | Chelate compound of a paramagnetic ion of lanthanide element | BRACCO INTERNATIONAL B.V. (NL) | 1995-12-12 | — | — | US | disclosed |
| EP-0394394-B1 | MANGANESE(II) CHELATES | NYCOMED SALUTAR INC (US) | 1995-01-18 | — | — | EP | disclosed |
| US-5155224-A | Protonated, insoluble magnetic resonance imaging contrast agents | SALUTAR, INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0232751-B1 | 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECANE AND ANALOGS | E.R. Squibb & Sons, Inc. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4978763-A | Novel manganese(II) DTPA chelate | SALUTAR, INC. (US) | 1990-12-18 | — | — | US | disclosed |
| EP-0394394-A1 | MANGANESE(II) CHELATES. | SALUTAR INC (US) | 1990-10-31 | — | — | EP | disclosed |
| EP-0369497-A1 | Manganese (II) chelates | SALUTAR, INC. (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1990003975-A1 | MANGANESE(II) CHELATES | SALUTAR, INC. (US) | 1990-04-19 | — | — | WO | disclosed |
| US-4889931-A | TREATING MANGANESE OXIDE WITH CHELATING AGENTS | SALUTAR, INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4885363-A | RADIOPHARMACEUTICAL IMAGING; MEDICAL DIAGNOSIS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0292689-A2 | Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs | BRACCO INTERNATIONAL B.V. (NL) | 1988-11-30 | — | — | EP | disclosed |
| EP-0232751-A1 | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs | E.R. Squibb & Sons, Inc. (US) | 1987-08-19 | — | — | EP | disclosed |