Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039163 | 1.00 | GSR (0.42) | GSRCYP2A6CYP2A13MEN1MAPT | |
| Lysine SCHEMBL7801478 | 0.91 | GSR (0.39) | GSRTHRBDPP8DPP7KIF11 | |
| Cyclohexylamine SCHEMBL8041402 | 0.88 | CYP2A6 (0.44) | CYP2A6CYP2A13MEN1MAPTKMT2A | |
| Cyclohexylamine SCHEMBL8041396 | 0.88 | CYP2A6 (0.44) | CYP2A6CYP2A13MEN1MAPTKMT2A | |
| Lysine SCHEMBL8035316 | 0.87 | GSR (0.46) | GSRTHRBDPP8DPP7KIF11 | |
| Lysine SCHEMBL8035311 | 0.87 | GSR (0.46) | GSRTHRBDPP8DPP7KIF11 | |
| Lysine SCHEMBL8039122 | 0.87 | GSR (0.48) | GSRKMT2ADPP8DPP7KIF11 | |
| Cuminaldehyde SCHEMBL8025615 | 0.86 | GSR (0.43) | GSRMEN1KMT2ATHRBDPP8 | |
| Lysine SCHEMBL8037527 | 0.86 | GSR (0.44) | GSRMAPTKMT2ADPP8DPP7 | |
| Lysine SCHEMBL8025620 | 0.86 | GSR (0.44) | GSRKMT2ADPP8DPP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |