SCHEMBL8040154

SCHEMBL8040154

CC#CCc1ccc(C#Cc2ccc(C3CCC(C)CC3)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.45
ACACB O00763 2/20 0.38
SPHK1 Q9NYA1 4/20 0.33
FFAR1 O14842 2/20 0.32
EGLN1 Q9GZT9 1/20 0.32
EGLN3 Q9H6Z9 1/20 0.32
GRM5 P41594 1/20 0.31
CYP2C19 P33261 2/20 0.31
ALDH1A1 P00352 2/20 0.31
CYP2D6 P10635 1/20 0.31
GLA P06280 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRB1 P18505 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8041060 0.85 ACACB (0.37) ESR2ACACBSPHK1ALDH1A1CYP2D6
SCHEMBL8046452 0.84 ESR2 (0.41) ESR2ACACBSPHK1GABRPGABRD
SCHEMBL8039114 0.84 ACACB (0.36) ACACBSPHK1FFAR1
SCHEMBL8039186 0.83 CYP2C9 (0.47) ESR2ACACBSPHK1ALDH1A1GABRP
SCHEMBL8046795 0.82 ACACB (0.31) ESR2ACACBFFAR1
SCHEMBL8039211 0.82 SPHK1 (0.41) ESR2SPHK1FFAR1GABRPGABRD
SCHEMBL8029358 0.81 SPHK1 (0.46) ESR2SPHK1FFAR1
SCHEMBL8029221 0.80 SPHK1 (0.42) SPHK1ALDH1A1LMNAMAPT
SCHEMBL8029233 0.80 ACACB (0.35) ACACBSPHK1
SCHEMBL8039827 0.80 PANK3 (0.31) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727473-B1 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-01-12 EP disclosed
US-5833879-A LOW TEMPERATURE MISCIBILITY AND COMPATIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS; DISPLAYS CONTAINING MIXTURES OF AT LEAST TWO COMPOUNDS, PHYSICAL PROPERTIES CHISSO CORPORATION (JP) 1998-11-10 US disclosed
EP-0727473-A2 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1996-08-21 EP disclosed