Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8041501 | 1.00 | GSR (0.41) | GSRGRM4THRBEPHX1KMT2A | |
| Cyclohexylamine SCHEMBL8025602 | 0.88 | EPHX1 (0.41) | GRM4EPHX1KMT2AAKR1C3MMP2 | |
| Cyclohexylamine SCHEMBL8025607 | 0.88 | EPHX1 (0.41) | GRM4EPHX1KMT2AAKR1C3MMP2 | |
| Lysine SCHEMBL8035311 | 0.86 | GSR (0.46) | GSRGRM4THRBCPB2DPP8 | |
| Lysine SCHEMBL8035316 | 0.86 | GSR (0.46) | GSRGRM4THRBCPB2DPP8 | |
| Lysine SCHEMBL8039122 | 0.86 | GSR (0.48) | GSRKMT2AMMP2CPB2DPP8 | |
| Cuminaldehyde SCHEMBL8025615 | 0.85 | GSR (0.43) | GSRTHRBEPHX1KMT2ACPB2 | |
| Lysine SCHEMBL8037527 | 0.85 | GSR (0.44) | GSRKMT2ADPP8 | |
| Lysine SCHEMBL8037285 | 0.85 | GSR (0.44) | GSRTHRBKMT2ACPB2DPP8 | |
| Lysine SCHEMBL8025620 | 0.85 | GSR (0.44) | GSRGRM4EPHX1KMT2AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |