Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916567 | 0.75 | CYP1A2 (0.48) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1165531 | 0.72 | CYP1A2 (0.41) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30528375 | 0.72 | CYP1A2 (0.41) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1397762 | 0.70 | CYP2A6 (0.62) | CYP2A6ALDH1A1ADORA3 | |
| SCHEMBL12317671 | 0.70 | KDM4E (0.41) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4820686 | 0.69 | CYP2A6 (0.52) | CYP2A6KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL29935718 | 0.69 | CYP2A6 (0.52) | CYP2A6KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL23293854 | 0.68 | CYP2A6 (0.42) | CYP2A6ADORA3 | |
| SCHEMBL2818516 | 0.68 | GAA (0.51) | CYP2A6KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL30947758 | 0.68 | CYP2A6 (0.42) | CYP2A6ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256299-A1 | 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |