Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.78 |
| ▸ | KDM1A | O60341 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | F3 | P13726 | 1/20 | 0.78 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087623 | 0.90 | HDAC1 (0.82) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL29838042 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL29387345 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL29499905 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL148309 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL2407986 | 0.87 | HDAC1 (0.98) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL2409897 | 0.87 | HDAC1 (0.98) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL2412431 | 0.85 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL2412014 | 0.84 | HDAC1 (0.93) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| Entinostat SCHEMBL2413749 | 0.84 | HDAC1 (0.93) | HDAC1HDAC3HDAC2HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064301-A1 | METHODS FOR DETECTING AND MONITORING CIRCULATING CANCER STEM CELLS | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009064789-A2 | METHODS FOR DETECTING AND MONITORING CIRCULATING CANCER STEM CELLS | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009064300-A1 | COMBINATIONS OF HDAC INHIBITORS AND CYTOKINES/GROWTH FACTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-05-22 | — | — | WO | disclosed |