SCHEMBL8042723

SCHEMBL8042723

NS(=O)(=O)c1ccc(-n2c(Sc3ncc(C(=O)O)s3)nnc2-c2cccs2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.48
CA1 P00915 7/20 0.46
CA2 P00918 7/20 0.46
CA9 Q16790 7/20 0.46
CA4 P22748 5/20 0.46
HSD17B10 Q99714 5/20 0.46
KDM4E B2RXH2 3/20 0.46
NPSR1 Q6W5P4 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
RECQL P46063 1/20 0.43
ALDH1A1 P00352 5/20 0.42
HPGD P15428 3/20 0.42
MEN1 O00255 1/20 0.42
PPARG P37231 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
NR2E3 Q9Y5X4 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8034049 0.89 TSHR (0.58) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8042001 0.88 HSD17B10 (0.50) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8050851 0.87 TSHR (0.49) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8046532 0.86 TSHR (0.48) TSHRCA1CA2CA9CA4
SCHEMBL8048208 0.84 TSHR (0.47) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8050243 0.84 NPSR1 (0.57) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8042043 0.84 TSHR (0.49) TSHRCA1CA2CA9CA4
SCHEMBL8043876 0.84 RECQL (0.50) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8043041 0.84 TSHR (0.49) TSHRHSD17B10KDM4ENPSR1SMN1; SMN2
SCHEMBL8033434 0.84 TSHR (0.46) TSHRCA1CA2CA9CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed