Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.81 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR5A | P47898 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409014 | 1.00 | HTR2C (0.81) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL1813749 | 1.00 | HTR2C (0.81) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL568047 | 0.98 | HTR2C (0.81) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8045704 | 0.98 | HTR2C (0.81) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL30952441 | 0.90 | HTR2C (0.66) | HTR2CHTR2AHTR1AHTR1DHTR1E | |
| SCHEMBL2145214 | 0.90 | HTR2C (0.66) | HTR2CHTR2AHTR1AHTR1DHTR1E | |
| SCHEMBL30952439 | 0.90 | HTR2C (0.66) | HTR2CHTR2AHTR1AHTR1DHTR1E | |
| SCHEMBL21359054 | 0.90 | HTR2C (0.66) | HTR2CHTR2AHTR1AHTR1DHTR1E | |
| SCHEMBL27995550 | 0.90 | HTR2C (0.66) | HTR2CHTR2AHTR1AHTR1DHTR1E | |
| SCHEMBL29891667 | 0.89 | HTR2C (1.00) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133275-A | ALPHA 1 ADRENORECEPTOR ANTAGONISTS; TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER UROLOGICAL DISEASES E.G., BLADDER OUTLET OBSTRUCTION), NEUROGENIC BLADDER AND GYNECOLOGICAL SYNDROMES, E.G., DYSMENORRHEA; UTERINE MUSCLE RELAXANTS | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1999057122-A1 | 3-PHENYLPYRROLE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |