Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045495 | 0.75 | HDAC1 (0.46) | KDM4ESMN1; SMN2 | |
| SCHEMBL10365074 | 0.75 | KDM4E (0.35) | CYP2A6KDM4ESMN1; SMN2 | |
| SCHEMBL14557095 | 0.74 | SNCA (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL8047389 | 0.73 | CA1 (0.49) | KDM4ESMN1; SMN2 | |
| SCHEMBL14392676 | 0.71 | CYP2A6 (0.61) | CYP2A6PTK2HDAC6CYP11B2CYP11B1 | |
| SCHEMBL14557099 | 0.69 | KDM4E (0.43) | POLBKDM4ESMN1; SMN2 | |
| SCHEMBL31417903 | 0.69 | CYP2A6 (0.44) | CYP2A6PTK2HDAC6CYP11B2CYP11B1 | |
| SCHEMBL30396089 | 0.69 | KDM4E (0.64) | CYP2A6KDM4ESMN1; SMN2 | |
| SCHEMBL969939 | 0.67 | KDM4E (0.59) | POLBKDM4ESMN1; SMN2 | |
| SCHEMBL969945 | 0.66 | PIK3CA (0.40) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |