Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 13/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 13/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 13/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919375 | 0.89 | PRSS1 (0.66) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8049961 | 0.83 | PRSS1 (0.56) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2921569 | 0.81 | PRSS1 (0.68) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8048840 | 0.80 | PRSS1 (0.62) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2915000 | 0.80 | PRSS1 (0.71) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2919915 | 0.77 | PRSS1 (0.73) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8046268 | 0.76 | PRSS1 (0.50) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3669135 | 0.76 | PRSS1 (0.60) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3438818 | 0.75 | PRSS1 (0.68) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3438816 | 0.75 | PRSS1 (0.70) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |