Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 7/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055806 | 0.87 | MAPK8 (0.54) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL8063344 | 0.83 | MAPK8 (0.63) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3756647 | 0.82 | MAPK8 (0.67) | MAPK8MAPK10MAPK9JAK2 | |
| SCHEMBL3754435 | 0.82 | MAPK8 (0.80) | MAPK8MAPK10MAPK9JAK2 | |
| SCHEMBL3752338 | 0.82 | MAPK8 (0.67) | MAPK8MAPK10MAPK9CAMK2DSTK17A | |
| SCHEMBL8055715 | 0.80 | JAK2 (0.55) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3748771 | 0.80 | MAPK8 (0.62) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3760571 | 0.80 | MAPK8 (0.65) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3748185 | 0.80 | MAPK8 (0.62) | MAPK8MAPK10MAPK9JAK2ACVR1 | |
| SCHEMBL3752892 | 0.79 | MAPK8 (0.78) | MAPK8MAPK10MAPK9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |