SCHEMBL8046362

SCHEMBL8046362

CCCC#CCc1ccc(C#Cc2ccc(-c3ccc(OC)cc3)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 4/20 0.50
APP P05067 2/20 0.45
MAOB P27338 2/20 0.42
ACACB O00763 3/20 0.41
KCNH2 Q12809 2/20 0.40
NAAA Q02083 1/20 0.38
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP3 P08254 1/20 0.38
MMP13 P45452 1/20 0.38
IDO1 P14902 1/20 0.37
ESR2 Q92731 1/20 0.37
CASP3 P42574 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8045734 0.95 APP (0.49) MCHR1APPMAOBACACBKCNH2
SCHEMBL8040194 0.91 MCHR1 (0.48) MCHR1APPMAOBACACBKCNH2
SCHEMBL3228125 0.89 IDO1 (0.45) MAOBIDO1
SCHEMBL8046338 0.88 MCHR1 (0.52) MCHR1APPMAOBACACBKCNH2
SCHEMBL8041089 0.87 ACACB (0.48) MCHR1ACACB
SCHEMBL8040012 0.86 APP (0.46) MCHR1APPMAOBACACBKCNH2
SCHEMBL8041309 0.84 CYP2A6 (0.41) ACACBKCNH2
SCHEMBL8029369 0.83 TSHR (0.41) ACACBMMP2
SCHEMBL8041073 0.83 KCNH2 (0.44) ACACBKCNH2
SCHEMBL8029216 0.83 APP (0.53) MCHR1APPMAOBACACBKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727473-B1 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-01-12 EP disclosed
US-5833879-A LOW TEMPERATURE MISCIBILITY AND COMPATIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS; DISPLAYS CONTAINING MIXTURES OF AT LEAST TWO COMPOUNDS, PHYSICAL PROPERTIES CHISSO CORPORATION (JP) 1998-11-10 US disclosed
EP-0727473-A2 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1996-08-21 EP disclosed