SCHEMBL8047950

SCHEMBL8047950

C/C=C/CCC1=CCC(c2ccc(-c3ccc(C#N)cc3)cc2)CC1

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 11/20 0.37
KCNH2 Q12809 1/20 0.37
HRH2 P25021 4/20 0.34
HRH1 P35367 4/20 0.34
PAX8 Q06710 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GRIA1 P42261 1/20 0.31
GRIA2 P42262 1/20 0.31
GRIA3 P42263 1/20 0.31
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8047956 1.00 HRH3 (0.37) HRH3KCNH2HRH2HRH1PAX8
SCHEMBL8054991 0.92 KCNH2 (0.33) HRH3KCNH2TSHRHSD17B10GRIA1
SCHEMBL8054988 0.92 KCNH2 (0.33) HRH3KCNH2TSHRHSD17B10GRIA1
SCHEMBL8047922 0.86 HRH3 (0.36) HRH3KCNH2HRH2HRH1PAX8
SCHEMBL8052425 0.85
SCHEMBL8052422 0.85
SCHEMBL8049220 0.84 TSHR (0.34) KCNH2TSHRHSD17B10
SCHEMBL8049223 0.84 TSHR (0.34) KCNH2TSHRHSD17B10
SCHEMBL8047513 0.84 PTGS1 (0.31)
SCHEMBL8047511 0.84 PTGS1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728829-B1 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-05-03 EP disclosed
US-5698136-A LOW TEMPERATURE COMPATIBILITY, CHEMICAL STABILITY CHISSO CORPORATION (JP) 1997-12-16 US disclosed
EP-0728829-A2 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORPORATION (JP) 1996-08-28 EP disclosed