SCHEMBL8048337

SCHEMBL8048337

O=C1C=C(c2c(Cl)cccc2Cl)C(=O)N1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.48
RET P07949 1/20 0.42
GRK5 P34947 1/20 0.42
TYRO3 Q06418 1/20 0.42
DYRK1B Q9Y463 1/20 0.42
NSD2 O96028 1/20 0.40
BCHE P06276 1/20 0.40
DAO P14920 1/20 0.40
TGM2 P21980 3/20 0.38
PBRM1 Q86U86 5/20 0.37
GRIA1 P42261 1/20 0.36
CACNG8 Q8WXS5 1/20 0.36
AHR P35869 1/20 0.35
HTR2A P28223 2/20 0.35
HTR2C P28335 2/20 0.35
HTR2B P41595 2/20 0.35
SMARCA2 P51531 1/20 0.35
SMARCA4 P51532 1/20 0.35
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL465066 0.82 CES1 (0.47) CES1AHRALDH1A1
SCHEMBL2343846 0.79 CES1 (0.44) CES1NSD2BCHEDAOTGM2
SCHEMBL187280 0.78 PTPRC (0.50) CES1NSD2BCHEDAOALDH1A1
Ammonia Solution, Strong SCHEMBL27972892 0.78 CES1 (0.43) CES1NSD2BCHEDAOTGM2
Ammonia Solution, Strong SCHEMBL27960588 0.77 PTPRC (0.49) CES1NSD2BCHEDAOALDH1A1
SCHEMBL505505 0.76 DAO (0.40) RETDAOPBRM1GRIA1CACNG8
SCHEMBL28002541 0.74 GSK3A (0.38) CES1RETDAOPBRM1GRIA1
SCHEMBL28156938 0.74 GSK3A (0.38) CES1RETDAOPBRM1GRIA1
SCHEMBL3677437 0.73 PDK2 (0.39) DAOHTR2AHTR2CHTR2B
SCHEMBL9587810 0.72 GSK3B (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634406-B1 DIGUANAMINE, AND PRODUCTION, DERIVATIVE AND USE THEREOF MITSUI CHEMICALS INC (JP) 2000-05-03 EP disclosed
US-5869184-A RESIN RAW MATERIALS FOR PAINTS, ADHESIVES MITSUI TOATSU CHEMICALS, INC. (JP) 1999-02-09 US disclosed
US-5744504-A AMINO RESIN; THERMOSETTING MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1998-04-28 US disclosed
US-5648446-A ADHESIVES, FIREPROOFING, HEAT RESISTANCE IN RESINS FOR MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1997-07-15 US disclosed
US-5646240-A THERMOSETTING MOLDING COMPOSITIONS MITSUI TOATSU CHEMICALS, INC. (JP) 1997-07-08 US disclosed
US-5596039-A FLAME RETARDERS, HEAT RESISTANCE MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1997-01-21 US disclosed
US-5569726-A USEFUL IN FLAME-RETARDING, THERMAL STABILIZATION AND COMPATIBILIZATION OF RESINS AND IN THERMOSETTING MOLDING COMPOSITIONS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-10-29 US disclosed
US-5545702-A THERMOSETTING RESIN COMPOSITION MITSUI TOATSU CHEMICALS, INC. (JP) 1996-08-13 US disclosed
US-5536795-A ADHESIVES AND PAINTS AND FIREPROOFING THERMOSETTING RESINS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5480947-A N-METHYLOL DIGUANAMINES MITSUI TOATSU CHEMICALS, INC. (JP) 1996-01-02 US disclosed
EP-0634406-A1 DIGUANAMINE, AND PRODUCTION, DERIVATIVE AND USE THEREOF MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-01-18 EP disclosed