Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290298 | 1.00 | F2 (0.34) | F2F10PRSS1GAAPLG | |
| SCHEMBL13685052 | 1.00 | F2 (0.34) | F2F10PRSS1GAAPLG | |
| SCHEMBL7858719 | 1.00 | F2 (0.34) | F2F10PRSS1GAAPLG | |
| SCHEMBL13685318 | 1.00 | F2 (0.34) | F2F10PRSS1GAAPLG | |
| SCHEMBL16315715 | 0.94 | GAA (0.35) | F2F10PRSS1GAAPLG | |
| SCHEMBL16349581 | 0.94 | GAA (0.35) | F2F10PRSS1GAAPLG | |
| SCHEMBL16349734 | 0.94 | GAA (0.35) | F2F10PRSS1GAAPLG | |
| SCHEMBL13685751 | 0.92 | F2 (0.32) | F2F10PRSS1GAABACE1 | |
| SCHEMBL8290536 | 0.90 | GAA (0.33) | F2F10PRSS1GAAPLG | |
| SCHEMBL13685100 | 0.88 | F2 (0.33) | F2F10PRSS1GAAPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058856-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |