Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044158 | 0.89 | TSHR (0.54) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8042778 | 0.85 | TSHR (0.43) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8042111 | 0.85 | TSHR (0.55) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8047465 | 0.83 | NPSR1 (0.47) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8041896 | 0.83 | TSHR (0.43) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8042040 | 0.83 | TSHR (0.43) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8042008 | 0.82 | HSD17B10 (0.49) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8048191 | 0.82 | TSHR (0.45) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8043594 | 0.81 | TSHR (0.43) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8042619 | 0.81 | TSHR (0.57) | TSHRHSD17B10KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |