SCHEMBL8048717

SCHEMBL8048717

CCC(C)CCC1CCC(c2ccc(CCc3ccc(OC(F)(F)F)c(F)c3)c(F)c2)CC1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.37
EPHX2 P34913 5/20 0.35
PDE2A O00408 3/20 0.33
HCRTR1 O43613 6/20 0.33
HCRTR2 O43614 6/20 0.33
CTSK P43235 1/20 0.31
NAAA Q02083 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM5 P08912 1/20 0.31
P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8045441 0.91 KCNH2 (0.39) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8048753 0.90 EPHX2 (0.34) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8049212 0.89 CHRM2 (0.31) CHRM2CHRM5
SCHEMBL8052428 0.89 EPHX2 (0.40) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8031354 0.88 CYP2C9 (0.36) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8046626 0.88 EPHX2 (0.40) KCNH2EPHX2PDE2ACHRM2CHRM5
SCHEMBL8048566 0.88 KCNH2 (0.39) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8748173 0.87 HCRTR1 (0.34) KCNH2EPHX2PDE2AHCRTR1HCRTR2
SCHEMBL8034519 0.86 EPHX2 (0.39) KCNH2EPHX2PDE2ACHRM2CHRM5
SCHEMBL8747919 0.86 SPHK1 (0.34) KCNH2EPHX2PDE2AHCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733692-B1 Liquid crystalline compound, liquid crystal composition containing the same, and display device CHISSO CORP (JP) 2000-06-14 EP disclosed
US-5714088-A TRIFLUOROMETHYL- OR -METHOXYPHENYL-SUBSTITUTED BRANCHED ALKYL-SUBSTITUTED CYCLOHEXANES; LARGE POSITIVE VALUE OF DIELECTRIC ANISOTROPY; VERY LOW VISCOSITY; HIGH VOLTAGE HOLDING RATIO(SPECIFIC RESISTANCE); UV STABILITY CHISSO CORPORATION (JP) 1998-02-03 US disclosed
CN-1140194-A Liquid crystalline compound having branched alkyl group at its side chain and liquid crystal composition containing the same CHISSO CORP (JP) 1997-01-15 CN disclosed
EP-0733692-A1 Liquid crystalline compound, liquid crystal composition containing the same, and display device Chisso Corporation (JP) 1996-09-25 EP disclosed