Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | SHBG | P04278 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SNCA | P37840 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol SCHEMBL961326 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL10039358 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL19235633 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL15610005 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL15610524 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL24037697 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL7037626 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL10039280 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL18258335 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL19217062 | 1.00 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 138229 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146967-A1 | DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE | REMINDED, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747643-A1 | DEVICES AND METHODS FOR IMMUNOASSAY ANALYSIS OF BIOLOGICAL SAMPLES | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| CN-115584331-B | Lactobacillus gasseri for reducing osteoporosis occurrence risk caused by low estrogen level and application thereof | JIANGNAN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-116687962-B | Composition for preventing or treating diabetes and application thereof | QINGDAO UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122084916-A | Fluorescent sensor for detecting endocrine disrupting activity in sewage and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080105-A | Estrol antidepressant derivative, preparation method and medical application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122072275-A | Detection of biomarkers in biological samples | 奥特森斯诊断有限公司 | 2026-05-22 | — | — | CN | claimed |
| WO-2026106440-A1 | MEDIUM COMPOSITION FOR IN VITRO FERTILIZATION AND/OR IN VITRO CULTURE OF AGED OOCYTES AND METHOD FOR IN VITRO FERTILIZATION AND/OR IN VITRO CULTURE USING SAME | 주식회사 미토이뮨테라퓨틱스 | 2026-05-21 | — | — | WO | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260137764-A1 | METHOD FOR CASTRATION OF ANIMALS | SHENZHEN HERZ LIFE SCIENCE TECHNOLOGY CO., LTD (CN) | 2026-05-21 | — | — | US | claimed |
| US-4009266-A | METHOD OF TREATMENT OF NEMATODE PARASITE INFECTIONS IN DOMESTIC ANIMALS | AYALEW LIYEW | 1977-02-22 | — | — | US | claimed |
| US-3993072-A | Microporous drug delivery device | ALZA CORPORATION (US) | 1976-11-23 | — | — | US | claimed |
| US-3989828-A | Mixed esters of estradiol and zeranol | ARIES ROBERT | 1976-11-02 | — | — | US | claimed |
| US-3975928-A | Synchronizing signal detecting apparatus for circular knitting machines | OKUMA MACHINERY WORKS, LTD. (JA) | 1976-08-24 | — | — | US | claimed |
| US-3962430-A | Sterilization of solid non-electrolyte medicinal agents employing sodium chloride | MERCK & CO., INC. (US) | 1976-06-08 | — | — | US | claimed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | claimed |
| US-3946106-A | POLYSILOXANES | G. D. SEARLE & CO. (US) | 1976-03-23 | — | — | US | claimed |
| US-3944358-A | Color image reproduction system | XEROX CORPORATION (US) | 1976-03-16 | — | — | US | claimed |
| US-3939265-A | MIXTURE OF AN ANABOLISANT AND ESTROGENIC STEROID | GRANDADAM JEAN ANDRE | 1976-02-17 | — | — | US | claimed |
| US-3939186-A | Process for producing ethers of steroids | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1976-02-17 | — | — | US | claimed |