Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129846 | 0.91 | PSEN1 (0.43) | SLC6A2SLC6A4SLC6A3PROKR1DRD2 | |
| SCHEMBL478267 | 0.91 | PSEN1 (0.47) | SLC6A4PROKR1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL478109 | 0.83 | PSEN1 (0.45) | SMN1; SMN2ALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8061191 | 0.83 | PSEN1 (0.45) | SMN1; SMN2ALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8071974 | 0.83 | PSEN1 (0.45) | SMN1; SMN2ALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8054379 | 0.83 | PSEN1 (0.46) | SLC6A4PROKR1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL8049173 | 0.83 | PSEN1 (0.46) | SLC6A4PROKR1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL478228 | 0.83 | PSEN1 (0.46) | SLC6A4PROKR1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL478140 | 0.81 | PSEN1 (0.44) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8080527 | 0.81 | PSEN1 (0.44) | ALDH1A1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009052126-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |