Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 14/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 14/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065207 | 0.91 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8050492 | 0.89 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8053186 | 0.82 | PIK3CA (0.76) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12945852 | 0.79 | PIK3CA (0.52) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12910221 | 0.78 | PIK3CA (0.56) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL8067087 | 0.75 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8053699 | 0.74 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8053124 | 0.73 | PIK3CA (0.49) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL8062411 | 0.73 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8067046 | 0.69 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045175-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |