Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 11/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760515 | 0.88 | MAPK10 (0.58) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL3754746 | 0.87 | MAPK10 (0.59) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL8052127 | 0.83 | MAPK10 (0.61) | MAPK10MAPK8JAK2MAPK9HDAC1 | |
| SCHEMBL3753577 | 0.81 | MAPK10 (0.79) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL8052148 | 0.80 | MAPK10 (0.53) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL3756008 | 0.80 | MAPK10 (0.55) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL3750455 | 0.79 | MAPK10 (0.52) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL8057480 | 0.79 | MAPK10 (0.59) | MAPK10MAPK8JAK2JAK3MAPK9 | |
| SCHEMBL15108219 | 0.79 | JAK2 (0.61) | JAK2JAK3HDAC1 | |
| SCHEMBL3753592 | 0.79 | MAPK10 (0.62) | MAPK10MAPK8JAK2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |