Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102116 | 0.83 | HSD17B10 (0.60) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL8429458 | 0.79 | HSD17B10 (0.66) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL2603227 | 0.77 | HSD17B10 (0.64) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL14393742 | 0.76 | HSD17B10 (0.62) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL2606058 | 0.75 | HSD17B10 (0.70) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31627544 | 0.74 | HSD17B10 (0.58) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL16216045 | 0.73 | HSD17B10 (0.71) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL18909382 | 0.73 | TSHR (0.61) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31717947 | 0.73 | HSD17B10 (1.00) | ALOX15TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL26981196 | 0.73 | HSD17B10 (0.91) | ALOX15TSHRHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |