Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 12/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 12/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 12/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109322 | 0.90 | PRSS1 (0.61) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8045760 | 0.90 | PRSS1 (0.58) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109267 | 0.88 | PRSS1 (0.59) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109134 | 0.88 | PRSS1 (0.59) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2111958 | 0.87 | PRSS1 (0.60) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2111643 | 0.86 | PRSS1 (0.63) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109200 | 0.86 | PRSS1 (0.59) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2110754 | 0.86 | PRSS1 (0.59) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109387 | 0.85 | PRSS1 (0.62) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2110026 | 0.84 | PRSS1 (0.61) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |