Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 14/20 | 0.50 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756024 | 0.93 | MAPK8 (0.67) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3750610 | 0.80 | JAK2 (0.72) | MAPK8MAPK10MAPK9JAK2CAMK2D | |
| SCHEMBL3760946 | 0.79 | JAK2 (0.54) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL8055327 | 0.78 | MAPK8 (0.68) | MAPK8MAPK10MAPK9JAK2MYLK4 | |
| SCHEMBL16404647 | 0.76 | MAPK8 (0.52) | MAPK8MAPK10MAPK9JAK2MYLK4 | |
| SCHEMBL3760957 | 0.75 | JAK2 (0.72) | MAPK8MAPK10JAK2JAK3JAK1 | |
| SCHEMBL3748329 | 0.74 | MAPK8 (0.77) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3758473 | 0.73 | MAPK10 (1.00) | MAPK8MAPK10MAPK9JAK2MYLK4 | |
| SCHEMBL3764213 | 0.73 | MAPK10 (0.75) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3748580 | 0.73 | MAPK8 (0.69) | MAPK8MAPK10MAPK9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |