Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.33 |
| ▸ | KCNQ1 known ✓ | P51787 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL7164562 | 0.87 | AKR1C3 (0.44) | AKR1C3APEX1PRSS1TMPRSS15CYP3A4 | |
| Guanidine SCHEMBL7164558 | 0.87 | AKR1C3 (0.44) | AKR1C3APEX1PRSS1TMPRSS15CYP3A4 | |
| Hydrochloric Acid SCHEMBL8054488 | 0.84 | KAT6A (0.34) | CXCR5SCN9AKIF11PTGS2CYP3A4 | |
| SCHEMBL7008624 | 0.78 | AKR1C3 (0.53) | AKR1C3APEX1CYP3A4 | |
| SCHEMBL7008627 | 0.78 | AKR1C3 (0.53) | AKR1C3APEX1CYP3A4 | |
| Guanidine SCHEMBL7163632 | 0.77 | AKR1C3 (0.40) | AKR1C3APEX1PRSS1TMPRSS15 | |
| Guanidine SCHEMBL7163626 | 0.77 | AKR1C3 (0.40) | AKR1C3APEX1PRSS1TMPRSS15 | |
| Acetic Acid SCHEMBL27677077 | 0.75 | KCNN4 (0.51) | AKR1C3KCNN4SCN9AKIF11PTGS2 | |
| Guanidine SCHEMBL7165528 | 0.75 | CYP1A2 (0.50) | AKR1C3APEX1PRSS1TMPRSS15CYP3A4 | |
| Guanidine SCHEMBL7165534 | 0.75 | CYP1A2 (0.50) | AKR1C3APEX1PRSS1TMPRSS15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025349-A | ANTIARRHYTHMIC PROPERTIES, | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |