Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060550 | 0.85 | EDNRA (0.71) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8390571 | 0.84 | EDNRA (0.46) | EDNRATSHREDNRB | |
| SCHEMBL8058105 | 0.80 | EDNRA (1.00) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8060425 | 0.79 | EDNRA (1.00) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8055525 | 0.79 | EDNRA (1.00) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8055569 | 0.79 | EDNRA (0.76) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8054280 | 0.78 | EDNRA (1.00) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8042538 | 0.77 | EDNRA (0.72) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8058102 | 0.76 | EDNRA (0.72) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8060464 | 0.75 | EDNRA (1.00) | EDNRAKDM4ETSHRHSD17B10NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083951-A | FOR THE TREATMENT OF DISEASES OR MEDICAL CONDITIONS SUCH AS HYPERTENSION, PULMONARY HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| US-5861401-A | TREATMENT OF CONGESTIVE HEART FAILURE | ZENECA LIMITED (GB) | 1999-01-19 | — | — | US | disclosed |
| EP-0752986-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026957-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1995-10-12 | — | — | WO | disclosed |