Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Udenafil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A known ✓ | O76074 | 20/20 | 0.75 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE9A | O76083 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE6C | P51160 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Udenafil SCHEMBL8065053 | 0.97 | PDE5A (0.74) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8055916 | 0.97 | PDE5A (0.71) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8064829 | 0.97 | PDE5A (0.79) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8055422 | 0.97 | PDE5A (0.74) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8065808 | 0.96 | PDE5A (0.75) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8056674 | 0.95 | PDE5A (0.73) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8066433 | 0.95 | PDE5A (0.70) | PDE5APDE3BPDE3A | |
| Udenafil SCHEMBL8055638 | 0.95 | PDE5A (0.83) | PDE5APDE2APDE9APDE4APDE6C | |
| Udenafil SCHEMBL8065506 | 0.95 | PDE5A (0.70) | PDE5APDE3BPDE3A | |
| Udenafil SCHEMBL8056008 | 0.95 | PDE5A (0.83) | PDE5APDE2APDE9APDE4APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | PDE5A, PDE7A, PDE3A | PDE5A 1/4885PDE2A 4/4885PDE9A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.