Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 12/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 12/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 12/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 12/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 12/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.43 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.43 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464140 | 0.89 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL3686484 | 0.86 | RXFP1 (0.54) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7957837 | 0.84 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL3686813 | 0.82 | KDM4E (0.48) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7958054 | 0.82 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7460818 | 0.81 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8062471 | 0.81 | GRIA1 (0.42) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7465885 | 0.80 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7465894 | 0.80 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7532574 | 0.78 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096744-A | ANTICONVULSANTS | WARNER-LAMBERT COMPANY (US) | 2000-08-01 | — | — | US | claimed |
| US-20100196354-A1 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| US-20100196354-A1 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| US-6096744-A | ANTICONVULSANTS | WARNER-LAMBERT COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196354-A1 | GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE | GRM5, GRM1, GRM3 | GRIA1 10/4885GRIA2 13/4885GRIA3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.