Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753807 | 0.91 | MAPK8 (0.56) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL16390751 | 0.86 | MAPK10 (0.61) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL3748771 | 0.84 | MAPK8 (0.62) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL3752338 | 0.83 | MAPK8 (0.67) | MAPK8MAPK10MAPK9ACVR1 | |
| SCHEMBL3754435 | 0.83 | MAPK8 (0.80) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3748185 | 0.83 | MAPK8 (0.62) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL8051697 | 0.82 | MAPK8 (0.58) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL3750965 | 0.79 | MAPK8 (0.79) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL8054696 | 0.77 | MAPK8 (0.51) | MAPK8MAPK10MAPK9CCNA2CDK2 | |
| SCHEMBL3764962 | 0.77 | MAPK8 (0.61) | MAPK8MAPK10MAPK9CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |